Mapping monocyte subsets to identify cardiovascular risk

Role and analysis of monocyte subsets in cardiovascular disease

Christian Weber1,2; Eduard Shantsila3; Michael Hristov1; Giuseppina Caligiuri4; Tomasz Guzik5,6; Gunnar H. Heine7; Imo E. Hoefer8; Claudia Monaco9; Karlheinz Peter10; Ed Rainger3; Agneta Siegbahn11; Sabine Steffens1,2; Johann Wojta12; Gregory Y. H. Lip3 1Institute for Cardiovascular Prevention, Ludwig-Maximilians-University (LMU), Munich, Germany; 2German Centre for Cardiovascular Research, Par...

Monocyte subsets in atherosclerosis.

Endothelial dysfunction and chronic inflammation of the arterial wall continuously drive the development of atherosclerotic lesions. Monocytes, as cells of the innate immunity, are particularly involved in this process. In the last decade, heterogeneity of circulating monocytes has widely been acknowledged, and a recent consensus nomenclature subdivides classical, intermediate and nonclassical ...

Human Blood Monocyte Subsets

Immunosuppression and monocyte subsets.

BACKGROUND Monocytes are critical in innate immunity and transplantation. Three monocyte subsets exist, CD14(++)CD16(-), CD14(++)CD16(+) and CD14(+)CD16(++) monocytes; cell counts of CD14(++)CD16(+) and CD14(+)CD16(++) monocytes are increased in pre-transplant chronic kidney disease. Interestingly, the effect of immunosuppressants on monocyte heterogeneity has not been well studied. METHODS T...

Blood Monocyte Subsets and Selected Cardiovascular Risk Markers in Rheumatoid Arthritis of Short Duration in relation to Disease Activity

OBJECTIVES To evaluate blood monocyte subsets and functional monocyte properties in patients with rheumatoid arthritis (RA) of short duration in the context of cardiovascular (CV) risk and disease activity. METHODS We studied conventional markers of CV risk, intima media thickness (IMT), and blood monocyte subsets in 27 patients aged 41 ± 10 years with RA of short duration (median 12 months) ...